EC 2.4.1.152 - 4-galactosyl-N-acetylglucosaminide 3-α-L-fucosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.152

Names

Accepted name:
4-galactosyl-N-acetylglucosaminide 3-α-L-fucosyltransferase
Other names:
GDP-L-fucose:1,4-β-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase
Lewis-negative α-3-fucosyltransferase
galactoside 3-fucosyltransferase
plasma α-3-fucosyltransferase
GDP-β-L-fucose:1,4-β-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase
guanosine diphosphofucose-glucoside α-1→3-fucosyltransferase
GDP-β-L-fucose:1,4-β-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-α-L-fucosyltransferase
Systematic name:
GDP-β-L-fucose:β-D-galactosyl-(1→4)-N-acetyl-D-glucosaminyl-R 3-α-L-fucosyltransferase

Reaction

Comments:

Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, 3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0017083
CAS Registry Number: 111310-38-4
UniProtKB/Swiss-Prot:

References

  1. Johnson, P.H., Yates, A.D. and Watkins, W.M.
    Human salivary fucosyltransferase: evidence for two distinct α-3-L-fucosyltransferase activities one of which is associated with the Lewis blood Le gene.
    Biochem. Biophys. Res. Commun. 100: 1611-1618 (1981). [PMID: 7295318]
  2. Schachter, H., Narasimhan, S., Gleeson, P. and Vella, G.
    Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
    Methods Enzymol. 98: 98-134 (1983). [PMID: 6366476]
  3. Ma, B., Wang, G., Palcic, M.M., Hazes, B. and Taylor, D.E.
    C-terminal amino acids of Helicobacter pylori α1,3/4 fucosyltransferases determine type I and type II transfer.
    J. Biol. Chem. 278: 21893-21900 (2003). [PMID: 12676935]

[EC 2.4.1.152 created 1984, modified 2002, modified 2019]