EC 2.4.1.146 - β-1,3-galactosyl-O-glycosyl-glycoprotein β-1,3-N-acetylglucosaminyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.146

Names

Accepted name:
β-1,3-galactosyl-O-glycosyl-glycoprotein β-1,3-N-acetylglucosaminyltransferase
Other names:
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
elongation 3β-GalNAc-transferase
uridine diphosphoacetylglucosamine-mucin β(1→3)-acetylglucosaminyltransferase (elongating)
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of β-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) β-1,3-N-acetyl-D-glucosaminyltransferase
UDP-N-acetyl-D-glucosamine:β-D-galactosyl-(1→3)-[N-acetyl-D-glucosaminyl-(1→6)]-N-acetyl-D-galactosaminyl-R 3-β-N-acetyl-D-glucosaminyltransferase
B3GNT3 (gene name)
Systematic name:
UDP-N-acetyl-α-D-glucosamine:3-O-{β-D-galactosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→6)]-N-acetyl-α-D-galactosaminyl}-L-seryl/threonyl-[protein] 3-β-N-acetyl-D-glucosaminyltransferase (configuration-inverting)

Reactions

Comments:

The enzyme catalyses the addition of N-acetyl-α-D-glucosamine to the core 2 structure of O-glycans.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047223
CAS Registry Number: 87927-99-9
UniProtKB/Swiss-Prot:

References

  1. Brockhausen, I., Rachaman, E.S., Matta, K.L. and Schachter, H.
    The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
    Carbohydr. Res. 120: 3-16 (1983). [PMID: 6226356]
  2. Shiraishi, N., Natsume, A., Togayachi, A., Endo, T., Akashima, T., Yamada, Y., Imai, N., Nakagawa, S., Koizumi, S., Sekine, S., Narimatsu, H., Sasaki, K.
    Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.
    J. Biol. Chem. 276: 3498-3507 (2001). [PMID: 11042166]

[EC 2.4.1.146 created 1984, modified 2018]