EC - Sucrose synthase

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IntEnz Enzyme Nomenclature


Accepted name:
sucrose synthase
Other names:
UDPglucose-fructose glucosyltransferase
sucrose synthetase
sucrose-UDP glucosyltransferase
sucrose-uridine diphosphate glucosyltransferase
uridine diphosphoglucose-fructose glucosyltransferase
UDP-glucose-fructose glucosyltransferase
NDP-glucose:D-fructose 2-α-D-glucosyltransferase
Systematic name:
NDP-α-D-glucose:D-fructose 2-α-D-glucosyltransferase (configuration-retaining)



Although UDP is generally considered to be the preferred nucleoside diphosphate for sucrose synthase, numerous studies have shown that ADP serves as an effective acceptor molecule to produce ADP-glucose [3-9]. Sucrose synthase has a dual role in producing both UDP-glucose (necessary for cell wall and glycoprotein biosynthesis) and ADP-glucose (necessary for starch biosynthesis) [10].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016157
CAS Registry Number: 9030-05-1
UniProtKB/Swiss-Prot: (38) [show] [UniProt]


  1. Avigad, G. and Milner, Y.
    UDP-glucose:fructose transglucosylase from sugar beet roots.
    Methods Enzymol. 8 : 341-345 (1966).
  2. Cardini, C.E., Leloir, L.F. and Chiriboga, J.
    The biosynthesis of sucrose.
    J. Biol. Chem. 214 : 149-155 (1955). [PMID: 14367373]
  3. Delmer, D.P.
    The purification and properties of sucrose synthetase from etiolated Phaseolus aureus seedlings.
    J. Biol. Chem. 247 : 3822-3828 (1972). [PMID: 4624446]
  4. Murata, T., Sugiyama, T., Minamikawa, T. and Akazawa, T.
    Enzymic mechanism of starch synthesis in ripening rice grains. Mechanism of the sucrose-starch conversion.
    Arch. Biochem. Biophys. 113 : 34-44 (1966). [PMID: 5941994]
  5. Nakai, T., Konishi, T., Zhang, X.-Q., Chollet, R., Tonouchi, N., Tsuchida, T., Yoshinaga, F., Mori, H., Sakai, F. and Hayashi, T.
    An increase in apparent affinity for sucrose of mung bean sucrose synthase is caused by in vitro phosphorylation or directed mutagenesis of Ser11.
    Plant Cell Physiol. 39 : 1337-1341 (1998). [PMID: 10050318]
  6. Porchia, A.C., Curatti, L. and Salerno, G.L.
    Sucrose metabolism in cyanobacteria: sucrose synthase from Anabaena sp. strain PCC 7119 is remarkably different from the plant enzymes with respect to substrate affinity and amino-terminal sequence.
    Planta 210 : 34-40 (1999). [PMID: 10592030]
  7. Ross, H.A. and Davies, H.V.
    Purification and characterization of sucrose synthase from the cotyledons of Vicia fava L.
    Plant Physiol. 100 : 1008-1013 (1992).
  8. Silvius, J.E. and Snyder, F.W.
    Comparative enzymic studies of sucrose metabolism in the taproots and fibrous roots of Beta vulgaris L.
    Plant Physiol. 64 : 1070-1073 (1979).
  9. Tanase, K. and Yamaki, S.
    Purification and characterization of two sucrose synthase isoforms from Japanese pear fruit.
    Plant Cell Physiol. 41 : 408-414 (2000). [PMID: 10845453]
  10. Baroja-Fernández, E., Muňoz, F.J., Saikusa, T., Rodríguez-López, M., Akazawa, T. and Pozueta-Romero, J.
    Sucrose synthase catalyzes the de novo production of ADPglucose linked to starch biosynthesis in heterotrophic tissues of plants.
    Plant Cell Physiol. 44 : 500-509 (2003). [PMID: 12773636]

[EC created 1961, modified 2003]