EC - Sucrose—1,6-α-glucan 3(6)-α-glucosyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
sucrose—1,6-α-glucan 3(6)-α-glucosyltransferase
Other names:
sucrose-1,6-α-glucan 3(6)-α-glucosyltransferase
sucrose:1,6-, 1,3-α-D-glucan 3-α- and 6-α-D-glucosyltransferase
sucrose:1,6-α-D-glucan 3-α- and 6-α-glucosyltransferase
water-soluble-glucan synthase [misleading]
sucrose:1,6-α-D-glucan 3(6)-α-D-glucosyltransferase
gtfB (gene name)
gtfC (gene name)
gtfD (gene name)
Systematic name:
sucrose:(1→6)-α-D-glucan 3(6)-α-D-glucosyltransferase



The enzyme was characterized from the dental caries bacterium Streptococcus mutans. It transfers glucosyl residues from sucrose to either the 6- or the 3-positions of glucose residues in glucans, producing a highly-branched extracellular D-glucan polymers that promote attachment of the bacteria to teeth. Three types of the enzyme have been described; the insoluble polymers produced by GTF-I and GTF-SI contain 85% α(1→3) bonds and 15% α(1→6) bonds, while the soluble polymers produced by GTF-S contain only 30% of α(1→3) bonds and 70% α(1→6) bonds. cf. EC, dextransucrase [5].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047217
CAS Registry Number: 81725-87-3


  1. Mukasa, H., Shimamura, A. and Tsumori, H.
    Purification and characterization of basic glucosyltransferase from Streptococcus mutans serotype c.
    Biochim. Biophys. Acta 719: 81-89 (1982). [PMID: 6216919]
  2. Shimamura, A., Tsumori, H. and Mukasa, H.
    Purification and properties of Streptococcus mutans extracellular glucosyltransferase.
    Biochim. Biophys. Acta 702: 72-80 (1982). [PMID: 6461359]
  3. Tsumori, H., Shimamura, A. and Mukasa, H.
    Purification and properties of extracellular glucosyltransferase synthesizing 1,6-, 1,3-α-D-glucan from Streptococcus mutans serotype a.
    J. Gen. Microbiol. 131: 3347-3353 (1985). [PMID: 2937877]
  4. Fujiwara, T., Tamesada, M., Bian, Z., Kawabata, S., Kimura, S., Hamada, S.
    Deletion and reintroduction of glucosyltransferase genes of Streptococcus mutans and role of their gene products in sucrose dependent cellular adherence.
    Microb. Pathog. 20: 225-233 (1996). [PMID: 8737492]
  5. Monchois, V., Willemot, R. M., Monsan, P.
    Glucansucrases: mechanism of action and structure-function relationships.
    FEMS Microbiol. Rev. 23: 131-151 (1999). [PMID: 10234842]
  6. Ito, K., Ito, S., Shimamura, T., Weyand, S., Kawarasaki, Y., Misaka, T., Abe, K., Kobayashi, T., Cameron, A. D., Iwata, S.
    Crystal structure of glucansucrase from the dental caries pathogen Streptococcus mutans.
    J. Mol. Biol. 408: 177-186 (2011). [PMID: 21354427]

[EC created 1984]