IntEnz

EC 2.4.1.11 - Glycogen(starch) synthase

IntEnz Enzyme Nomenclature
EC 2.4.1.11

Names

Reaction

• 18549 [IUBMB]
  [(1→4)-α-D-glucosyl]_(n)

  [(1->4)-alpha-D-glucosyl](n)

  POLYMER:9584

  Formula: H2O(C6H10O5)_n
  Charge: (0)(0)_n

  ChEBI polymer: CHEBI:15444

  

  +

  UDP-α-D-glucose

  UDP-alpha-D-glucose

  Name origin: UniProt - CHECKED (C)

  CHEBI:58885

  Formula: C15H22N2O17P2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  =

  [(1→4)-α-D-glucosyl]_(n+1)

  [(1->4)-alpha-D-glucosyl](n+1)

  POLYMER:9587

  Formula: H2O(C6H10O5)_n+1
  Charge: (0)(0)_n+1

  ChEBI polymer: CHEBI:15444

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  UDP

  UDP

  Name origin: UniProt - CHECKED (C)

  CHEBI:58223

  Formula: C9H11N2O12P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

Comments:

The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).

Links to other databases

References

1. Algranati, I.D. and Cabib, E.
   The synthesis of glycogen in yeast.
   Biochim. Biophys. Acta 43 : 141-142 (1960). [PMID: 13682402]
2. Basu, D.K. and Bachhawat, B.K.
   Purification of uridine diphosphoglucose-glycogen transglucosylase from sheep brain.
   Biochim. Biophys. Acta 50 : 123-128 (1961). [PMID: 13687710]
3. Leloir, L.F. and Cardini, C.E.
   UDPG-glycogen transglucosylase.
   In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes , 2nd ed. vol. 6 , Academic Press , New York , 1962 , 317-326
4. Leloir, L.F. and Goldemberg, S.H.
   Synthesis of glycogen from uridine diphosphate glucose in liver.
   J. Biol. Chem. 235 : 919-923 (1960).
5. Pitcher, J., Smythe, C. and Cohen, P.
   Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle.
   Eur. J. Biochem. 176 : 391-395 (1988). [PMID: 2970965]

[EC 2.4.1.11 created 1961]