EC 2.4.1.11 - Glycogen(starch) synthase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.4.1.11
Names
Accepted name:
glycogen(starch) synthase
Other
names:
UDP-glucose—glycogen glucosyltransferase
UDP-glycogen synthase
UDPG-glycogen synthetase
UDPG-glycogen transglucosylase
UDPglucose:glycogen 4-α-D-glucosyltransferase
glycogen (starch) synthetase
uridine diphosphoglucose-glycogen glucosyltransferase
UDP-α-D-glucose:glycogen 4-α-D-glucosyltransferase
UDP-glycogen synthase
UDPG-glycogen synthetase
UDPG-glycogen transglucosylase
UDPglucose:glycogen 4-α-D-glucosyltransferase
glycogen (starch) synthetase
uridine diphosphoglucose-glycogen glucosyltransferase
UDP-α-D-glucose:glycogen 4-α-D-glucosyltransferase
Systematic name:
UDP-α-D-glucose:glycogen 4-α-D-glucosyltransferase (configuration-retaining)
Reaction
- UDP-alpha-D-glucose + [(1right4)-alpha-D-glucosyl]n = UDP + [(1right4)-alpha-D-glucosyl]n+1
Comments:
The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).
Links to other databases
Enzymes and pathways:
NC-IUBMB
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BRENDA
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DIAGRAM
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ExplorEnz
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ENZYME@ExPASy
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KEGG
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MetaCyc
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UniPathway
Gene Ontology:
GO:0004373
CAS Registry Number:
9014-56-6
References
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The synthesis of glycogen in yeast.Biochim. Biophys. Acta 43 : 141-142 (1960). [PMID: 13682402]
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Purification of uridine diphosphoglucose-glycogen transglucosylase from sheep brain.Biochim. Biophys. Acta 50 : 123-128 (1961). [PMID: 13687710]
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UDPG-glycogen transglucosylase.In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes , 2nd ed. vol. 6 , Academic Press , New York , 1962 , 317-326
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Synthesis of glycogen from uridine diphosphate glucose in liver.J. Biol. Chem. 235 : 919-923 (1960).
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Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle.Eur. J. Biochem. 176 : 391-395 (1988). [PMID: 2970965]
[EC 2.4.1.11 created 1961]