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EC 2.4.1.11 - Glycogen(starch) synthase

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IntEnz Enzyme Nomenclature
EC 2.4.1.11

Names

Accepted name:

glycogen(starch) synthase

Other names:

UDP-glucose—glycogen glucosyltransferase
UDP-glycogen synthase
UDPG-glycogen synthetase
UDPG-glycogen transglucosylase
UDPglucose:glycogen 4-α-D-glucosyltransferase
glycogen (starch) synthetase
uridine diphosphoglucose-glycogen glucosyltransferase
UDP-α-D-glucose:glycogen 4-α-D-glucosyltransferase

Systematic name:

UDP-α-D-glucose:glycogen 4-α-D-glucosyltransferase (configuration-retaining)

Reaction

18549 [IUBMB]

[(1→4)-α-D-glucosyl]_(n)

[(1->4)-alpha-D-glucosyl](n)

POLYMER:9584

Formula: H2O(C6H10O5)_n
Charge: (0)(0)_n

ChEBI polymer: CHEBI:15444

+

UDP-α-D-glucose

UDP-alpha-D-glucose

Name origin: UniProt - CHECKED (C)

CHEBI:58885

Formula: C15H22N2O17P2
Charge: -2

ChEBI compound status: CHECKED (C)

=

[(1→4)-α-D-glucosyl]_(n+1)

[(1->4)-alpha-D-glucosyl](n+1)

POLYMER:9587

Formula: H2O(C6H10O5)_n+1
Charge: (0)(0)_n+1

ChEBI polymer: CHEBI:15444

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

UDP

UDP

Name origin: UniProt - CHECKED (C)

CHEBI:58223

Formula: C9H11N2O12P2
Charge: -3

ChEBI compound status: CHECKED (C)

Comments:

The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0004373

CAS Registry Number: 9014-56-6

UniProtKB/Swiss-Prot: (18) [show] [UniProt]

References

Algranati, I.D. and Cabib, E.

The synthesis of glycogen in yeast.

Biochim. Biophys. Acta 43: 141-142 (1960). [PMID: 13682402]
Basu, D.K. and Bachhawat, B.K.

Purification of uridine diphosphoglucose-glycogen transglucosylase from sheep brain.

Biochim. Biophys. Acta 50: 123-128 (1961). [PMID: 13687710]
Leloir, L.F. and Cardini, C.E.

UDPG-glycogen transglucosylase.

In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes, 2nd ed. vol. 6, Academic Press, New York, 1962, 317-326
Leloir, L.F. and Goldemberg, S.H.

Synthesis of glycogen from uridine diphosphate glucose in liver.

J. Biol. Chem. 235: 919-923 (1960).
Pitcher, J., Smythe, C. and Cohen, P.

Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle.

Eur. J. Biochem. 176: 391-395 (1988). [PMID: 2970965]

[EC 2.4.1.11 created 1961]

EC 2 - Transferases