EC 2.4.1.11 - Glycogen(starch) synthase

  IntEnz view ENZYME view
XML

IntEnz Enzyme Nomenclature
EC 2.4.1.11

Names

Accepted name:
glycogen(starch) synthase
Other names:
UDP-glucose—glycogen glucosyltransferase
UDP-glycogen synthase
UDPG-glycogen synthetase
UDPG-glycogen transglucosylase
UDPglucose:glycogen 4-α-D-glucosyltransferase
glycogen (starch) synthetase
uridine diphosphoglucose-glycogen glucosyltransferase
UDP-α-D-glucose:glycogen 4-α-D-glucosyltransferase
Systematic name:
UDP-α-D-glucose:glycogen 4-α-D-glucosyltransferase (configuration-retaining)

Reaction

Comments:

The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004373
CAS Registry Number: 9014-56-6
UniProtKB/Swiss-Prot: (20) [show] [UniProt]

References

  1. Algranati, I.D. and Cabib, E.
    The synthesis of glycogen in yeast.
    Biochim. Biophys. Acta 43 : 141-142 (1960). [PMID: 13682402]
  2. Basu, D.K. and Bachhawat, B.K.
    Purification of uridine diphosphoglucose-glycogen transglucosylase from sheep brain.
    Biochim. Biophys. Acta 50 : 123-128 (1961). [PMID: 13687710]
  3. Leloir, L.F. and Cardini, C.E.
    UDPG-glycogen transglucosylase.
    In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes , 2nd ed. vol. 6 , Academic Press , New York , 1962 , 317-326
  4. Leloir, L.F. and Goldemberg, S.H.
    Synthesis of glycogen from uridine diphosphate glucose in liver.
    J. Biol. Chem. 235 : 919-923 (1960).
  5. Pitcher, J., Smythe, C. and Cohen, P.
    Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle.
    Eur. J. Biochem. 176 : 391-395 (1988). [PMID: 2970965]

[EC 2.4.1.11 created 1961]