EC - Dolichyl-phosphate-mannose—protein mannosyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
dolichyl-phosphate-mannose—protein mannosyltransferase
Other names:
dolichol phosphomannose-protein mannosyltransferase
protein O-D-mannosyltransferase
dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase
dolichyl-phosphate-mannose-protein mannosyltransferase
dolichyl-D-mannosyl-phosphate:protein O-D-mannosyltransferase
Systematic name:
dolichyl-D-mannosyl-phosphate::L-threonyl/L-seryl-[protein] O-D-mannosyltransferase (configuration-inverting)



The enzyme transfers mannosyl residues to the hydroxy group of serine or threonine residues, producing cell-wall mannoproteins. It acts only on long-chain α-dihydropolyprenyl derivatives, larger than C35.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004169
CAS Registry Number: 74315-99-4
UniProtKB/Swiss-Prot: (63) [show] [UniProt]


  1. Babczinski, P., Haselbeck, A. and Tanner, W.
    Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme.
    Eur. J. Biochem. 105 : 509-515 (1980). [PMID: 6989607]
  2. Palamarczyk, G., Lehle, L., Mankowski, T., Chojnacki, T. and Tanner, W.
    Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives.
    Eur. J. Biochem. 105 : 517-523 (1980). [PMID: 6445267]

[EC created 1983, modified 2014]