EC 2.4.1.102 - β-1,3-galactosyl-O-glycosyl-glycoprotein β-1,6-N-acetylglucosaminyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.102

Names

Accepted name:
β-1,3-galactosyl-O-glycosyl-glycoprotein β-1,6-N-acetylglucosaminyltransferase
Other names:
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
β6-N-acetylglucosaminyltransferase
core 2 acetylglucosaminyltransferase
core 6-β-GlcNAc-transferase A
uridine diphosphoacetylglucosamine-mucin β-(1→6)-acetylglucosaminyltransferase
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of β-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) β-1,6-N-acetyl-D-glucosaminyltransferase
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of β-D-galactosyl-(1→3)-N-acetyl-D-galactosaminyl-R) 6-β-N-acetyl-D-glucosaminyltransferase
GCNT1
GCNT3
Systematic name:
UDP-N-acetyl-α-D-glucosamine:O3-[β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl]-L-glycoprotein 6-β-N-acetyl-D-glucosaminyltransferase (configuration-inverting)

Reactions

Comments:

The enzyme catalyses the addition of N-acetyl-α-D-glucosamine to the core 1 structure of O-glycans forming core 2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003829
CAS Registry Number: 95978-15-7
UniProtKB/Swiss-Prot: (19) [show] [UniProt]

References

  1. Brockhausen, I., Rachaman, E.S., Matta, K.L. and Schachter, H.
    The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
    Carbohydr. Res. 120: 3-16 (1983). [PMID: 6226356]
  2. Williams, D., Longmore, G., Matta, K.L. and Schachter, H.
    Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Galβ1-3GalNAc(GlcNAc→GalNAc) β6-N-acetylglucosaminyltransferase.
    J. Biol. Chem. 255: 11253-11261 (1980). [PMID: 6449508]
  3. Williams, D. and Schachter, H.
    Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates.
    J. Biol. Chem. 255: 11247-11252 (1980). [PMID: 6449507]

[EC 2.4.1.102 created 1983]