EC - Malate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
malate synthase
Other names:
L-malate glyoxylate-lyase (CoA-acetylating)
glyoxylate transacetylase
glyoxylate transacetase
glyoxylic transacetase
malate condensing enzyme
malate synthetase
malic synthetase
malic-condensing enzyme
acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Systematic name:
acetyl-CoA:glyoxylate C-acetyltransferase [(S)-malate-forming]



The enzyme catalyses the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO2. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00441
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004474
CAS Registry Number: 9013-48-3
UniProtKB/Swiss-Prot: (112) [show] [UniProt]


  1. Dixon, G. H., Kornberg, H.L. and Lund, P.
    Purification and properties of malate synthetase.
    Biochim. Biophys. Acta 41 : 217-233 (1960). [PMID: 13816984]
  2. Molina, I., Pellicer, M. T., Badia, J., Aguilar, J., Baldoma, L.
    Molecular characterization of Escherichia coli malate synthase G. Differentiation with the malate synthase A isoenzyme.
    Eur. J. Biochem. 224 : 541-548 (1994). [PMID: 7925370]
  3. Anstrom, D. M., Kallio, K., Remington, S. J.
    Structure of the Escherichia coli malate synthase G:pyruvate:acetyl-coenzyme A abortive ternary complex at 1.95 A resolution.
    Protein Sci. 12 : 1822-1832 (2003). [PMID: 12930982]
  4. Smith, C. V., Huang, C. C., Miczak, A., Russell, D. G., Sacchettini, J. C., Honer zu Bentrup, K.
    Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis.
    J. Biol. Chem. 278 : 1735-1743 (2003). [PMID: 12393860]

[EC created 1961 as EC, transferred 2002 to EC]