EC - Citrate (Re)-synthase

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IntEnz Enzyme Nomenclature


Accepted name:
citrate (Re)-synthase
Other names:
(R)-citrate synthase
citrate oxaloacetate-lyase [(pro-3R)-CH2COO→acetyl-CoA]
Systematic name:
acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]



This enzyme is inactivated by oxygen and is found in some anaerobes. Its stereospecificity is opposite to that of EC, citrate (Si)-synthase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050450
CAS Registry Number: 9077-70-7


  1. Dittbrenner, S., Chowdhury, A.A. and Gottschalk, G.
    The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate.
    Biochem. Biophys. Res. Commun. 36 : 802-808 (1969). [PMID: 5808294]
  2. Gottschalk, G.
    Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici.
    Eur. J. Biochem. 7 : 301-306 (1969). [PMID: 4974734]
  3. Gottschalk, G. and Barker, H.A.
    Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase.
    Biochemistry 5 : 1125-1133 (1966). [PMID: 5958189]

[EC created 1972 as EC, transferred 2002 to EC]