EC - 2-isopropylmalate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
2-isopropylmalate synthase
Other names:
3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)
α-isopropylmalate synthase
α-isopropylmalate synthetase
α-isopropylmalic synthetase
isopropylmalate synthase
isopropylmalate synthetase
Systematic name:
acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)




Requires K+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00643 , PROSITE:PDOC50991
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003852
CAS Registry Number: 9030-98-2
UniProtKB/Swiss-Prot: (419) [show] [UniProt]


  1. Kohlhaw, G., Leary, T.R. and Umbarger, H.E.
    α-Isopropylmalate synthase from Salmonella typhimurium. Purification and properties.
    J. Biol. Chem. 244 : 2218-2225 (1969). [PMID: 4976555]
  2. Webster, R.E. and Gross, S.R.
    The α-isopropylmalate synthetase of Neurospora. I. The kinetics and end product control of α-isopropylmalate synthetase function.
    Biochemistry 4 : 2309-2327 (1965).
  3. Cole, F.E., Kalyanpur, M.G. and Stevens, C.M.
    Absolute configuration of alpha isopropylmalate and the mechanism of its conversion to beta isopropylmalate in the biosynthesis of leucine.
    Biochemistry 12 : 3346-3350 (1973). [PMID: 4270046]

[EC created 1972 as EC, transferred 2002 to EC]