IntEnz

EC 2.3.3.10 - Hydroxymethylglutaryl-CoA synthase

IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.3.3.10

Names

Accepted name:

hydroxymethylglutaryl-CoA synthase

Other names:

(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
3-hydroxy-3-methylglutaryl CoA synthetase
3-hydroxy-3-methylglutaryl coenzyme A synthase
3-hydroxy-3-methylglutaryl coenzyme A synthetase
3-hydroxy-3-methylglutaryl-CoA synthase
3-hydroxy-3-methylglutaryl-coenzyme A synthase
β-hydroxy-β-methylglutaryl-CoA synthase
HMG-CoA synthase
acetoacetyl coenzyme A transacetase
hydroxymethylglutaryl coenzyme A synthase
hydroxymethylglutaryl coenzyme A-condensing enzyme

Systematic name:

acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)

Reaction

10188 [IUBMB]

acetoacetyl-CoA

acetoacetyl-CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57286

Formula: C25H36N7O18P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

acetyl-CoA

acetyl-CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57288

Formula: C23H34N7O17P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

H₂O

H2O

Name origin: UniProt - CHECKED (C)

CHEBI:15377

Formula: H2O
Charge: 0

ChEBI compound status: CHECKED (C)

=

(3S)-hydroxy-3-methylglutaryl-CoA

(3S)-hydroxy-3-methylglutaryl-CoA

Name origin: UniProt - CHECKED (C)

CHEBI:43074

Formula: C27H39N7O20P3S
Charge: -5

ChEBI compound status: CHECKED (C)

+

CoA

CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57287

Formula: C21H32N7O16P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)