EC - Hydroxymethylglutaryl-CoA synthase

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IntEnz Enzyme Nomenclature


Accepted name:
hydroxymethylglutaryl-CoA synthase
Other names:
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
3-hydroxy-3-methylglutaryl CoA synthetase
3-hydroxy-3-methylglutaryl coenzyme A synthase
3-hydroxy-3-methylglutaryl coenzyme A synthetase
3-hydroxy-3-methylglutaryl-CoA synthase
3-hydroxy-3-methylglutaryl-coenzyme A synthase
β-hydroxy-β-methylglutaryl-CoA synthase
HMG-CoA synthase
acetoacetyl coenzyme A transacetase
hydroxymethylglutaryl coenzyme A synthase
hydroxymethylglutaryl coenzyme A-condensing enzyme
Systematic name:
acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)


Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00942
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004421
CAS Registry Number: 9027-44-5
UniProtKB/Swiss-Prot: (32) [show] [UniProt]


  1. Rudney, H.
    The biosynthesis of β-hydroxy-β-methylglutaric acid.
    J. Biol. Chem. 227 : 363-377 (1957).

[EC created 1961 as EC, transferred 2002 to EC]