IntEnz

EC 2.3.2.5 - Glutaminyl-peptide cyclotransferase

IntEnz Enzyme Nomenclature
EC 2.3.2.5

Names

Reaction

• 23652 [IUBMB]
  N-terminal L-glutaminyl-[peptide]

  N-terminal L-glutaminyl-[peptide]

  GENERIC:11846

  Is ROOT: no
  ROOT compound: GENERIC:9779

  Number of residues: 1

  N-terminal L-glutamine residue N-terminal L-glutamine residue Name origin: UniProt - CHECKED (C) CHEBI:64722 Formula: C5H10N2O2 Charge: 1 Position: undefined ChEBI compound status: CHECKED (C)

  =

  N-terminal 5-oxo-L-prolyl-[peptide]

  N-terminal 5-oxo-L-prolyl-[peptide]

  GENERIC:11736

  Is ROOT: no
  ROOT compound: GENERIC:9779

  Number of residues: 1

  N-terminal 5-oxo-L-proline residue N-terminal 5-oxo-L-proline residue Name origin: UniProt - CHECKED (C) CHEBI:87215 Formula: C5H6NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  +

  NH₄⁺

  NH4(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:28938

  Formula: H4N
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Comments:

Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA.

Links to other databases

References

1. Busby, W.H., Quackenbush, G.E., Humm, J., Youngblood, W.W. and Kizer, J.S.
   An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes.
   J. Biol. Chem. 262: 8532-8536 (1987). [PMID: 3597387]
2. Fischer, W.H. and Spiess, J.
   Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides.
   Proc. Natl. Acad. Sci. USA 84: 3628-3632 (1987). [PMID: 3473473]
3. Messer, M. and Ottesen, M.
   Isolation and properties of glutamine cyclotransferase of dried papaya latex.
   C.R. Trav. Lab. Carlsberg 35: 1-24 (1965).

[EC 2.3.2.5 created 1972, modified 1990]