EC 2.3.2.5 - Glutaminyl-peptide cyclotransferase
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IntEnz Enzyme Nomenclature
EC 2.3.2.5
Names
Accepted name:
glutaminyl-peptide cyclotransferase
Other
names:
glutaminyl cyclase
glutaminyl-tRNA cyclotransferase
glutaminyl-transfer ribonucleate cyclotransferase
glutaminyl-tRNA cyclotransferase
glutaminyl-transfer ribonucleate cyclotransferase
Systematic name:
L-glutaminyl-peptide γ-glutamyltransferase (cyclizing)
Reaction
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23652 [IUBMB]N-terminal L-glutaminyl-[peptide]GENERIC:11846Is ROOT: no
ROOT compound: GENERIC:9779Number of residues: 1=N-terminal 5-oxo-L-prolyl-[peptide]GENERIC:11736Is ROOT: no
ROOT compound: GENERIC:9779Number of residues: 1
Comments:
Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA.
Links to other databases
Gene Ontology:
GO:0016603
CAS Registry Number:
37257-21-9
References
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An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes.J. Biol. Chem. 262 : 8532-8536 (1987). [PMID: 3597387]
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Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides.Proc. Natl. Acad. Sci. USA 84 : 3628-3632 (1987). [PMID: 3473473]
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Isolation and properties of glutamine cyclotransferase of dried papaya latex.C.R. Trav. Lab. Carlsberg 35 : 1-24 (1965).
[EC 2.3.2.5 created 1972, modified 1990]