EC - Capsaicin synthase

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IntEnz Enzyme Nomenclature


Accepted name:
capsaicin synthase
Systematic name:
(6E)-8-methylnon-6-enoyl-CoA:vanillylamine 8-methylnon-6-enoyltranferase



The enzyme, found only in plants that belong to the Capsicum genus, catalyses the last step in the biosynthesis of capsaicinoids. The enzyme catalyses the acylation of vanillylamine by a branched-chain fatty acid. The exact structure of the fatty acid determines the type of capsaicinoid formed.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Blum, E., Liu, K., Mazourek, M., Yoo, E. Y., Jahn, M., Paran, I.
    Molecular mapping of the C locus for presence of pungency in Capsicum.
    Genome 45 : 702-705 (2002). [PMID: 12175073]
  2. Stewart, C., Kang, B. C., Liu, K., Mazourek, M., Moore, S. L., Yoo, E. Y., Kim, B. D., Paran, I., Jahn, M. M., Jahn, M. M.
    The Pun1 gene for pungency in pepper encodes a putative acyltransferase.
    Plant J. 42 : 675-688 (2005). [PMID: 15918882]
  3. Kim, S., Park, M., Yeom, S.I., Kim, Y.M., Lee, J.M., Lee, H.A., Seo, E., Choi, J., Cheong, K., Kim, K.T., Jung, K., Lee, G.W., Oh, S.K., Bae, C., Kim, S.B., Lee, H.Y., Kim, S.Y., Kim, M.S., Kang, B.C., Jo, Y.D., Yang, H.B., Jeong, H.J., Kang, W.H., Kwon, J.K., Shin, C., Lim, J.Y., Park, J.H., Huh, J.H., Kim, J.S., Kim, B.D., Cohen, O., Paran, I., Suh, M.C., Lee, S.B., Kim, Y.K., Shin, Y., Noh, S.J., Park, J., Seo, Y.S., Kwon, S.Y., Kim, H.A., Park, J.M., Kim, H.J., Choi, S.B., Bosland, P.W., Reeves, G., Jo, S.H., Lee, B.W., Cho, H.T., Choi, H.S., Lee, M.S., Yu, Y., Do Choi, Y., Park, B.S., van Deynze, A., Ashrafi, H., Hill, T., Kim, W.T., Pai, H.S., Ahn, H.K., Yeam, I., Giovannoni, J.J., Rose, J.K., Sørensen, I., Lee, S.J., Kim, R.W., Choi, I.Y., Choi, B.S., Lim, J.S., Lee, Y.H. and Choi, D.
    Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum species.
    Nat. Genet. 46 : 270-278 (2014). [PMID: 24441736]

[EC created 2020]