EC - RCR-type E3 ubiquitin transferase

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IntEnz Enzyme Nomenclature


Accepted name:
RCR-type E3 ubiquitin transferase
Other names:
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RCR-type)



RCR-type E3 ubiquitin transferases is a class of RING-type E3 ubiquitin transferase (see EC that mediates ubiquitylation of acceptor proteins via an internal cysteine residue. The RING1 domain binds an EC, E2 ubiquitin-conjugating enzyme, and transfers the ubiquitin that is bound to it to an internal cysteine residue on a mediator loop of the RCR-type ligase. The ubiquitin may be transferred to a second internal cysteine before the transfer of the ubiquitin from the RCR-type ligase to the substrate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Pao, K. C., Wood, N. T., Knebel, A., Rafie, K., Stanley, M., Mabbitt, P. D., Sundaramoorthy, R., Hofmann, K., van Aalten, D. M. F., Virdee, S.
    Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.
    Nature 556 : 381-385 (2018). [PMID: 29643511]

[EC created 2019]