EC 2.3.2.12 - Peptidyltransferase
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IntEnz Enzyme Nomenclature
EC 2.3.2.12
Names
Accepted name:
peptidyltransferase
Other
names:
transpeptidase
ribosomal peptidyltransferase
ribosomal peptidyltransferase
Systematic name:
peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase
Reaction
- peptidyl-tRNA1 + aminoacyl-tRNA2 = tRNA1 + peptidyl(aminoacyl-tRNA2)
Comments:
The enzyme is a ribozyme. Two non-equivlant ribonucleoprotein subunits operate in non-concerted fashion in peptide elongation. The small subunit forms the mRNA-binding machinery and decoding center, the large subunit performs the main ribosomal catalytic function in the peptidyl-transferase center.
Links to other databases
Gene Ontology:
GO:0000048
CAS Registry Number:
9059-29-4
References
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Release of lysine peptides by puromycin from polylysyl-transfer ribonucleic acid in the presence of ribosomes.Biochim. Biophys. Acta 114 : 425-427 (1966). [PMID: 5329275]
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Substrate specificity of ribosomal peptidyl transferase: 2'(3')-O-aminoacyl nucleosides as acceptors of the peptide chain on the amino acid site.J. Mol. Biol. 43 : 13-24 (1969). [PMID: 4897787]
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The puromycin reaction and its relation to protein synthesis.J. Mol. Biol. 10 : 63-72 (1964).
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Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome.Nat. Struct. Mol. Biol. 16 : 528-533 (2009). [PMID: 19363482]
[EC 2.3.2.12 created 1976, modified 2010]