EC 18.104.22.168 - Peptidyltransferase
IntEnz Enzyme Nomenclature
- peptidyl-tRNA1 + aminoacyl-tRNA2 = tRNA1 + peptidyl(aminoacyl-tRNA2)
The enzyme is a ribozyme. Two non-equivlant ribonucleoprotein subunits operate in non-concerted fashion in peptide elongation. The small subunit forms the mRNA-binding machinery and decoding center, the large subunit performs the main ribosomal catalytic function in the peptidyl-transferase center.
Links to other databases
Release of lysine peptides by puromycin from polylysyl-transfer ribonucleic acid in the presence of ribosomes.Biochim. Biophys. Acta 114: 425-427 (1966). [PMID: 5329275]
Substrate specificity of ribosomal peptidyl transferase: 2'(3')-O-aminoacyl nucleosides as acceptors of the peptide chain on the amino acid site.J. Mol. Biol. 43: 13-24 (1969). [PMID: 4897787]
The puromycin reaction and its relation to protein synthesis.J. Mol. Biol. 10: 63-72 (1964).
Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome.Nat. Struct. Mol. Biol. 16: 528-533 (2009). [PMID: 19363482]
[EC 22.214.171.124 created 1976, modified 2010]