EC - Fatty-acid synthase system

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IntEnz Enzyme Nomenclature


Accepted name:
fatty-acid synthase system
Other names:
FASN (gene name)
fatty-acid synthase
Systematic name:
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)



The animal enzyme is a multi-functional protein catalysing the reactions of EC [acyl-carrier-protein] S-acetyltransferase, EC [acyl-carrier-protein] S-malonyltransferase, EC β-ketoacyl-[acyl-carrier-protein] synthase I, EC 3-oxoacyl-[acyl-carrier-protein] reductase, EC 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC oleoyl-[acyl-carrier-protein] hydrolase. cf. EC, fatty-acyl-CoA synthase system.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004312
CAS Registry Number: 9045-77-6


  1. Stoops, J.K., Ross, P., Arslanian, M.J., Aune, K.C., Wakil, S.J. and Oliver, R.M.
    Physicochemical studies of the rat liver and adipose fatty acid synthetases.
    J. Biol. Chem. 254 : 7418-7426 (1979). [PMID: 457689]
  2. Wakil, S.J., Stoops, J.K. and Joshi, V.C.
    Fatty acid synthesis and its regulation.
    Annu. Rev. Biochem. 52 : 537-579 (1983). [PMID: 6137188]

[EC created 1984, modified 2018]