EC 2.3.1.82 - Aminoglycoside 6'-N-acetyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.82

Names

Accepted name:
aminoglycoside 6'-N-acetyltransferase
Other names:
aminoglycoside N6'-acetyltransferase
aminoglycoside-6'-acetyltransferase
aminoglycoside-6-N-acetyltransferase
kanamycin acetyltransferase
kanamycin 6'-N-acetyltransferase
AAC(6')
6'-aminoglycoside-N-acetyltransferase
Systematic name:
acetyl-CoA:kanamycin-B N6'-acetyltransferase

Reaction

Comments:

The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin C1a, gentamicin C2 and sisomicin are substrates. The antibiotics gentamicin, tobramycin and neomycin, but not paromomycin, can also act as acceptors. The 6-amino group of the purpurosamine ring is acetylated.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047663
CAS Registry Number: 56467-65-3
UniProtKB/Swiss-Prot: (12) [show] [UniProt]

References

  1. le Goffic, F. and Martel, A.
    La résistance aux aminosides provoquée par une isoenzyme la kanamycine acétyltransférase.
    Biochimie (Paris) 56 : 893-897 (1974). [PMID: 4614862]
  2. Benveniste, R. and Davies, J.E.
    Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.
    Biochemistry 10 : 1787-1796 (1971). [PMID: 4935296]
  3. Dowding, J.E.
    Mechanisms of gentamicin resistance in Staphylococcus aureus.
    Antimicrob. Agents Chemother. 11 : 47-50 (1977). [PMID: 836013]

[EC 2.3.1.82 created 1976 as EC 2.3.1.55, transferred 1999 to EC 2.3.1.82, modified 1999, modified 2015]