EC - Chalcone synthase

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IntEnz Enzyme Nomenclature


Accepted name:
chalcone synthase
Other names:
6'-deoxychalcone synthase
naringenin-chalcone synthase
chalcone synthetase
flavanone synthase
Systematic name:
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)



The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00403
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102128 , GO:0016210
CAS Registry Number: 56803-04-4
UniProtKB/Swiss-Prot: (140) [show] [UniProt]


  1. Ayabe, S.-I., Udagawa, A. and Furuya, T.
    NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract.
    Arch. Biochem. Biophys. 261 : 458-462 (1988). [PMID: 3355160]
  2. Heller, W. and Hahlbrock, K.
    Highly purified "flavanone synthase" from parsley catalyzes the formation of naringenin chalcone.
    Arch. Biochem. Biophys. 200 : 617-619 (1980). [PMID: 7436427]
  3. Yahyaa, M., Ali, S., Davidovich-Rikanati, R., Ibdah, M., Shachtier, A., Eyal, Y., Lewinsohn, E., Ibdah, M.
    Characterization of three chalcone synthase-like genes from apple (Malus x domestica Borkh.).
    Phytochemistry 140 : 125-133 (2017). [PMID: 28482241]

[EC created 1984, modified 2018]