EC - Choline O-acetyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
choline O-acetyltransferase
Other names:
choline acetylase
choline acetyltransferase
Systematic name:
acetyl-CoA:choline O-acetyltransferase



Propanoyl-CoA can act, more slowly, in place of acetyl-CoA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00402
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004102
CAS Registry Number: 9012-78-6


  1. Berman, R., Wilson, I.B. and Nachmansohn, D.
    Choline acetylase specificity in relation to biological function.
    Biochim. Biophys. Acta 12: 315-324 (1953). [PMID: 13115440]
  2. Berry, J.F. and Whittaker, V.P.
    The acyl-group specificity of choline acetylase.
    Biochem. J. 73: 447-458 (1959). [PMID: 13799882]
  3. Fritz, I.B. and Schultz, S.K.
    Carnitine acetyltransferase. II. Inhibition by carnitine analogues and by sulfhydryl reagents.
    J. Biol. Chem. 240: 2188-2192 (1965). [PMID: 14299645]
  4. Schuberth, J.
    Choline acetyltransferase. Purification and effect of salts on the mechanism of the enzyme-catalysed reaction.
    Biochim. Biophys. Acta 122: 470-481 (1966).

[EC created 1961]