IntEnz

EC 2.3.1.57 - Diamine N-acetyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.57

Names

Accepted name:

diamine N-acetyltransferase

Other names:

acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase
diamine acetyltransferase
putrescine (diamine)-acetylating enzyme
putrescine N-acetyltransferase
putrescine acetylase
putrescine acetyltransferase
spermidine N¹-acetyltransferase
spermidine acetyltransferase
spermidine/spermine N¹-acetyltransferase

Systematic name:

acetyl-CoA:alkane-α,ω-diamine N-acetyltransferase

Reactions

11116 [IUBMB]

acetyl-CoA

acetyl-CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57288

Formula: C23H34N7O17P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

an alkane-α,ω-diamine

an alkane-alpha,omega-diamine

POLYMER:9766

Formula: C2H10N2(CH2)_n
Charge: (2)(0)_n

ChEBI polymer: CHEBI:70977

=

an N-acetylalkane-α,ω-diamine

an N-acetylalkane-alpha,omega-diamine

POLYMER:9767

Formula: C4H11N2O(CH2)_n
Charge: (1)(0)_n

ChEBI polymer: CHEBI:70988

+

CoA

CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57287

Formula: C21H32N7O16P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)
25181

acetyl-CoA

acetyl-CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57288

Formula: C23H34N7O17P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

putrescine

putrescine

Name origin: UniProt - CHECKED (C)

CHEBI:326268

Formula: C4H14N2
Charge: 2

ChEBI compound status: CHECKED (C)

=

CoA

CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57287

Formula: C21H32N7O16P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

N-acetylputrescine

N-acetylputrescine

Name origin: UniProt - CHECKED (C)

CHEBI:58263

Formula: C6H15N2O
Charge: 1

ChEBI compound status: CHECKED (C)
28150

acetyl-CoA

acetyl-CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57288

Formula: C23H34N7O17P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

spermidine

spermidine

Name origin: UniProt - CHECKED (C)

CHEBI:57834

Formula: C7H22N3
Charge: 3

ChEBI compound status: CHECKED (C)

=

CoA

CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57287

Formula: C21H32N7O16P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

N¹-acetylspermidine

N(1)-acetylspermidine

Name origin: UniProt - CHECKED (C)

CHEBI:58324

Formula: C9H23N3O
Charge: 2

ChEBI compound status: CHECKED (C)
28270

acetyl-CoA

acetyl-CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57288

Formula: C23H34N7O17P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

spermidine

spermidine

Name origin: UniProt - CHECKED (C)

CHEBI:57834

Formula: C7H22N3
Charge: 3

ChEBI compound status: CHECKED (C)

=

CoA

CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57287

Formula: C21H32N7O16P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

N⁸-acetylspermidine

N(8)-acetylspermidine

Name origin: UniProt - CHECKED (C)

CHEBI:58535

Formula: C9H23N3O
Charge: 2

ChEBI compound status: CHECKED (C)
33099

acetyl-CoA

acetyl-CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57288

Formula: C23H34N7O17P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

spermine

spermine

Name origin: UniProt - CHECKED (C)

CHEBI:45725

Formula: C10H30N4
Charge: 4

ChEBI compound status: CHECKED (C)

=

CoA

CoA

Name origin: UniProt - CHECKED (C)

CHEBI:57287

Formula: C21H32N7O16P3S
Charge: -4

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

N¹-acetylspermine

N(1)-acetylspermine

Name origin: UniProt - CHECKED (C)

CHEBI:58101

Formula: C12H31N4O
Charge: 3

ChEBI compound status: CHECKED (C)

Comments:

Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N¹- and N⁸-acetylspermidine), spermine, N¹-acetylspermidine and N⁸-acetylspermidine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Structural data: CSA , EC2PDB

Gene Ontology: GO:0004145

CAS Registry Number: 54596-36-0

UniProtKB/Swiss-Prot: (23) [show] [UniProt]

References

Della Ragione, F. and Pegg, A.E.

Purification and characterization of spermidine/spermine N¹-acetyltransferase from rat liver.

Biochemistry 21: 6152-6158 (1982). [PMID: 7150547]

[EC 2.3.1.57 created 1976, modified 1989]

EC 2 - Transferases