EC 2.3.1.50 - Serine C-palmitoyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.50

Names

Accepted name:
serine C-palmitoyltransferase
Other names:
3-oxosphinganine synthetase
SPT
acyl-CoA:serine C-2 acyltransferase decarboxylating
serine palmitoyltransferase
Systematic name:
palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)

Reaction

Cofactor

Comments:

A pyridoxal-phosphate protein.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00518
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004758
CAS Registry Number: 62213-50-7
UniProtKB/Swiss-Prot: (37) [show] [UniProt]

References

  1. Brady, R.N., DiMari, S.J. and Snell, E.E.
    Biosynthesis of sphingolipid bases. 3. Isolation and characterization of ketonic intermediates in the synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri.
    J. Biol. Chem. 244 : 491-496 (1969). [PMID: 4388074]
  2. Stoffel, W., Le Kim, D. and Sticht, G.
    Biosynthesis of dihydrosphingosine in vitro.
    Hoppe-Seyler's Z. Physiol. Chem. 349 : 664-670 (1968). [PMID: 4386961]

[EC 2.3.1.50 created 1976, modified 1982]