EC 2 - Transferases
EC 2.3 - Acyltransferases
EC 2.3.1 - Transferring groups other than amino-acyl groups
EC 2.3.1.48 - Histone acetyltransferase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.3.1.48
Names
Accepted name:
histone acetyltransferase
Other
names:
histone acetokinase
histone acetylase
histone transacetylase
nucleosome-histone acetyltransferase
lysine acetyltransferase
protein lysine acetyltransferase
acetyl-CoA:histone acetyltransferase
histone acetylase
histone transacetylase
nucleosome-histone acetyltransferase
lysine acetyltransferase
protein lysine acetyltransferase
acetyl-CoA:histone acetyltransferase
Systematic name:
acetyl-CoA:[protein]-L-lysine acetyltransferase
Reaction
- acetyl-CoA + protein-L-lysine = CoA + protein-N6-acetyl-L-lysine
Comments:
A group of enzymes acetylating histones. Several of the enzymes can also acetylate lysines in other proteins [3,4].
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ERGO
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0004402
CAS Registry Number:
9054-51-7
References
-
Histone acetylation. Purification and properties of three histone-specific acetyltransferases from rat thymus nuclei.Biochim. Biophys. Acta 263 : 315-328 (1972). [PMID: 5031160]
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Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase.J. Biol. Chem. 276 : 43499-43502 (2001). [PMID: 11585814]
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Histone acetyltransferase complexes: one size doesn't fit all.Nat. Rev. Mol. Cell Biol. 8 : 284-295 (2007). [PMID: 17380162]
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Biochemical and thermodynamic analyses of Salmonella enterica Pat, a multidomain, multimeric Nε-lysine acetyltransferase involved in carbon and energy metabolism.MBio 2 : E216 (2011). [PMID: 22010215]
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Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1.Proc. Natl. Acad. Sci. U.S.A. 109 : 8925-8930 (2012). [PMID: 22615379]
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Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.Proc. Natl. Acad. Sci. U.S.A. 111 : E1072-E1081 (2014). [PMID: 24616510]
[EC 2.3.1.48 created 1976, modified 2017]