EC 2 - Transferases
EC 2.3 - Acyltransferases
EC 2.3.1 - Transferring groups other than amino-acyl groups
EC 2.3.1.43 - Phosphatidylcholine—sterol O-acyltransferase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.3.1.43
Names
Accepted name:
phosphatidylcholine—sterol O-acyltransferase
Other
names:
LCAT (lecithin-cholesterol acyltransferase)
lecithin:cholesterol acyltransferase
lecithin—cholesterol acyltransferase
lysolecithin acyltransferase
phospholipid—cholesterol acyltransferase
lecithin:cholesterol acyltransferase
lecithin—cholesterol acyltransferase
lysolecithin acyltransferase
phospholipid—cholesterol acyltransferase
Systematic name:
phosphatidylcholine:sterol O-acyltransferase
Reaction
- phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester
Comments:
Palmitoyl, oleoyl and linoleoyl residues can be transferred; a number of sterols, including cholesterol, can act as acceptors. The bacterial enzyme also catalyses the reactions of EC 3.1.1.4 phospholipase A2 and EC 3.1.1.5 lysophospholipase.
Links to other databases
Protein domains and families:
PROSITE:PDOC00110
Gene Ontology:
GO:0004607
CAS Registry Number:
9031-14-5
References
-
Biosynthesis of sterol esters in Phycomyces blakesleeanus.Phytochemistry 13 : 1107-1113 (1974).
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Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase.J. Biol. Chem. 257 : 3320-3325 (1982). [PMID: 7061477]
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The plasma lecithins:cholesterol acyltransferase reaction.Lipid Res. 9 : 155-167 (1968). [PMID: 4868699]
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Enzymatic synthesis and hydrolysis of cholesterol esters.Methods Biochem. Anal. 16 : 219-272 (1968). [PMID: 4877146]
[EC 2.3.1.43 created 1972, modified 1976]