EC 2.3.1.43 - Phosphatidylcholine—sterol O-acyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.43

Names

Accepted name:
phosphatidylcholine—sterol O-acyltransferase
Other names:
LCAT (lecithin-cholesterol acyltransferase)
lecithin:cholesterol acyltransferase
lecithin—cholesterol acyltransferase
lysolecithin acyltransferase
phospholipid—cholesterol acyltransferase
Systematic name:
phosphatidylcholine:sterol O-acyltransferase

Reaction

Comments:

Palmitoyl, oleoyl and linoleoyl residues can be transferred; a number of sterols, including cholesterol, can act as acceptors. The bacterial enzyme also catalyses the reactions of EC 3.1.1.4 phospholipase A2 and EC 3.1.1.5 lysophospholipase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00110
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004607
CAS Registry Number: 9031-14-5
UniProtKB/Swiss-Prot: (12) [show] [UniProt]

References

  1. Bartlett, K., Keat, M.J. and Mercer, E.I.
    Biosynthesis of sterol esters in Phycomyces blakesleeanus.
    Phytochemistry 13 : 1107-1113 (1974).
  2. Buckley, J.T., Halasa, L.N. and Macintyre, S.
    Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase.
    J. Biol. Chem. 257 : 3320-3325 (1982). [PMID: 7061477]
  3. Glomset, J.A.J.
    The plasma lecithins:cholesterol acyltransferase reaction.
    Lipid Res. 9 : 155-167 (1968). [PMID: 4868699]
  4. Vahouny, G.V. and Tradwell, C.R.
    Enzymatic synthesis and hydrolysis of cholesterol esters.
    Methods Biochem. Anal. 16 : 219-272 (1968). [PMID: 4877146]

[EC 2.3.1.43 created 1972, modified 1976]