EC 2.3.1.296 - ω-hydroxyceramide transacylase

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IntEnz Enzyme Nomenclature
EC 2.3.1.296

Names

Accepted name:
ω-hydroxyceramide transacylase
Systematic name:
triacyl-sn-glycerol:ultra-long-chain ω-hydroxyceramide ω-O-linoleoyltransferase

Reactions

Comments:

The enzyme participates in the production of acylceramides in the stratum corneum, the outermost layer of the epidermis. Acylceramides are crucial components of the skin permeability barrier.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Ohno, Y., Kamiyama, N., Nakamichi, S., Kihara, A.
    PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ?-O-acylceramide.
    Nat Commun 8 : 14610 (2017). [PMID: 28248318]

[EC 2.3.1.296 created 2019]