EC 2.3.1.288 - 2-O-sulfo trehalose long-chain-acyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.288

Names

Accepted name:
2-O-sulfo trehalose long-chain-acyltransferase
Systematic name:
acyl-CoA:2-O-sulfo-α,α-trehalose 2'-long-chain-acyltransferase

Reactions

Comments:

This mycobacterial enzyme catalyses the acylation of 2-O-sulfo-α,α-trehalose at the 2' position by a C16 or C18 fatty acyl group during the biosynthesis of mycobacterial sulfolipids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Kumar, P., Schelle, M. W., Jain, M., Lin, F. L., Petzold, C. J., Leavell, M. D., Leary, J. A., Cox, J. S., Bertozzi, C. R.
    PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.
    Proc. Natl. Acad. Sci. U.S.A. 104 : 11221-11226 (2007). [PMID: 17592143]
  2. Seeliger, J. C., Holsclaw, C. M., Schelle, M. W., Botyanszki, Z., Gilmore, S. A., Tully, S. E., Niederweis, M., Cravatt, B. F., Leary, J. A., Bertozzi, C. R.
    Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis.
    J. Biol. Chem. 287 : 7990-8000 (2012). [PMID: 22194604]

[EC 2.3.1.288 created 2019]