EC - 2-O-sulfo trehalose long-chain-acyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
2-O-sulfo trehalose long-chain-acyltransferase
Systematic name:
acyl-CoA:2-O-sulfo-α,α-trehalose 2'-long-chain-acyltransferase



This mycobacterial enzyme catalyses the acylation of 2-O-sulfo-α,α-trehalose at the 2' position by a C16 or C18 fatty acyl group during the biosynthesis of mycobacterial sulfolipids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Kumar, P., Schelle, M. W., Jain, M., Lin, F. L., Petzold, C. J., Leavell, M. D., Leary, J. A., Cox, J. S., Bertozzi, C. R.
    PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.
    Proc. Natl. Acad. Sci. U.S.A. 104 : 11221-11226 (2007). [PMID: 17592143]
  2. Seeliger, J. C., Holsclaw, C. M., Schelle, M. W., Botyanszki, Z., Gilmore, S. A., Tully, S. E., Niederweis, M., Cravatt, B. F., Leary, J. A., Bertozzi, C. R.
    Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis.
    J. Biol. Chem. 287 : 7990-8000 (2012). [PMID: 22194604]

[EC created 2019]