EC - 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase
Systematic name:
3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-α,α-trehalose:3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-α,α-trehalose 6,6'-di(hydroxy)phthioceranyltransferase



The enzyme, present in mycobacteria, catalyses the ultimate step in the biosynthesis of mycobacterial sulfolipids. It catalyses two successive transfers of a (hydroxy)phthioceranyl group from two diacylated intermediates to third diacylated intermediate, generating the tetraacylated sulfolipid.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Seeliger, J. C., Holsclaw, C. M., Schelle, M. W., Botyanszki, Z., Gilmore, S. A., Tully, S. E., Niederweis, M., Cravatt, B. F., Leary, J. A., Bertozzi, C. R.
    Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis.
    J. Biol. Chem. 287 : 7990-8000 (2012). [PMID: 22194604]

[EC created 2019]