EC 2.3.1.284 - 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.284

Names

Accepted name:
3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase
Systematic name:
3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-α,α-trehalose:3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-α,α-trehalose 6,6'-di(hydroxy)phthioceranyltransferase

Reaction

Comments:

The enzyme, present in mycobacteria, catalyses the ultimate step in the biosynthesis of mycobacterial sulfolipids. It catalyses two successive transfers of a (hydroxy)phthioceranyl group from two diacylated intermediates to third diacylated intermediate, generating the tetraacylated sulfolipid.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Seeliger, J. C., Holsclaw, C. M., Schelle, M. W., Botyanszki, Z., Gilmore, S. A., Tully, S. E., Niederweis, M., Cravatt, B. F., Leary, J. A., Bertozzi, C. R.
    Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis.
    J. Biol. Chem. 287 : 7990-8000 (2012). [PMID: 22194604]

[EC 2.3.1.284 created 2019]