EC 2.3.1.283 - 2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.3.1.283

Names

Accepted name:
2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase
Systematic name:
(hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase]:2'-acyl-2-O-sulfo-α,α-trehalose 3'-(hydroxy)phthioceranyltransferase

Reaction

Comments:

This mycobacterial enzyme catalyses the acylation of 2'-palmitoyl/stearoyl-2-O-sulfo-α,α-trehalose at the 3' position by a (hydroxy)phthioceranoyl group during the biosynthesis of mycobacterial sulfolipids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Bhatt, K., Gurcha, S. S., Bhatt, A., Besra, G. S., Jacobs, W. R.
    Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.
    Microbiology (Reading, Engl.) 153 : 513-520 (2007). [PMID: 17259623]
  2. Kumar, P., Schelle, M. W., Jain, M., Lin, F. L., Petzold, C. J., Leavell, M. D., Leary, J. A., Cox, J. S., Bertozzi, C. R.
    PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.
    Proc. Natl. Acad. Sci. U.S.A. 104 : 11221-11226 (2007). [PMID: 17592143]

[EC 2.3.1.283 created 2019]