EC 184.108.40.2063 - 2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase
IntEnz Enzyme Nomenclature
- a (hydroxy)phthioceranyl-(hydroxy)phthioceranic acid synthase + 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose = a 3'-(hydroxy)phthioceranyl-2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose + holo-(hydroxy)phthioceranic acid synthase
This mycobacterial enzyme catalyses the acylation of 2'-palmitoyl/stearoyl-2-O-sulfo-α,α-trehalose at the 3' position by a (hydroxy)phthioceranoyl group during the biosynthesis of mycobacterial sulfolipids.
Links to other databases
Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.Microbiology (Reading, Engl.) 153 : 513-520 (2007). [PMID: 17259623]
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.Proc. Natl. Acad. Sci. U.S.A. 104 : 11221-11226 (2007). [PMID: 17592143]
[EC 220.127.116.113 created 2019]