EC 2.3.1.282 - Phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.282

Names

Accepted name:
phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase
Systematic name:
mycocerosyl-[mycocerosic acid synthase]:phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase

Reactions

Comments:

The enzyme, present in certain pathogenic species of mycobacteria, catalyses the transfer of mycocerosic acids to the two hydroxyl groups at the common lipid core of phthiocerol, phthiodiolone, and phenolphthiocerol, forming dimycocerosate esters. The fatty acid precursors of mycocerosic acids are activated by EC 6.2.1.49, long-chain fatty acid adenylyltransferase FadD28, which loads them onto EC 2.3.1.111, mycocerosate synthase. That enzyme extends the precursors to form mycocerosic acids that remain attached until transferred by EC 2.3.1.282.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (11) [show] [UniProt]

References

  1. Onwueme, K. C., Ferreras, J. A., Buglino, J., Lima, C. D., Quadri, L. E.
    Mycobacterial polyketide-associated proteins are acyltransferases: proof of principle with Mycobacterium tuberculosis PapA5.
    Proc. Natl. Acad. Sci. U.S.A. 101 : 4608-4613 (2004). [PMID: 15070765]
  2. Buglino, J., Onwueme, K. C., Ferreras, J. A., Quadri, L. E., Lima, C. D.
    Crystal structure of PapA5, a phthiocerol dimycocerosyl transferase from Mycobacterium tuberculosis.
    J. Biol. Chem. 279 : 30634-30642 (2004). [PMID: 15123643]
  3. Chavadi, S. S., Onwueme, K. C., Edupuganti, U. R., Jerome, J., Chatterjee, D., Soll, C. E., Quadri, L. E.
    The mycobacterial acyltransferase PapA5 is required for biosynthesis of cell wall-associated phenolic glycolipids.
    Microbiology (Reading, Engl.) 158 : 1379-1387 (2012). [PMID: 22361940]
  4. Touchette, M. H., Bommineni, G. R., Delle Bovi, R. J., Gadbery, J. E., Nicora, C. D., Shukla, A. K., Kyle, J. E., Metz, T. O., Martin, D. W., Sampson, N. S., Miller, W. T., Tonge, P. J., Seeliger, J. C.
    Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl ?-Diol Lipids.
    Biochemistry 54 : 5457-5468 (2015). [PMID: 26271001]

[EC 2.3.1.282 created 2019]