EC - 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase
Systematic name:
3-oxoacyl-[acyl-carrier protein]:glycerone phosphate 3-oxonacylltransferase



The enzyme catalyses the first committed step in the biosynthesis of γ-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Horinouchi, S., Suzuki, H., Nishiyama, M., Beppu, T.
    Nucleotide sequence and transcriptional analysis of the Streptomyces griseus gene (afsA) responsible for A-factor biosynthesis.
    J. Bacteriol. 171 : 1206-1210 (1989). [PMID: 2492509]
  2. Kato, J. Y., Funa, N., Watanabe, H., Ohnishi, Y., Horinouchi, S.
    Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.
    Proc. Natl. Acad. Sci. U.S.A. 104 : 2378-2383 (2007). [PMID: 17277085]
  3. Hsiao, N. H., Soding, J., Linke, D., Lange, C., Hertweck, C., Wohlleben, W., Takano, E.
    ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize gamma-butyrolactones.
    Microbiology (Reading, Engl.) 153 : 1394-1404 (2007). [PMID: 17464053]
  4. Lee, Y. J., Kitani, S., Nihira, T.
    Null mutation analysis of an afsA-family gene, barX, that is involved in biosynthesis of the {gamma}-butyrolactone autoregulator in Streptomyces virginiae.
    Microbiology (Reading, Engl.) 156 : 206-210 (2010). [PMID: 19778967]

[EC created 2018]