IntEnz

EC 2.3.1.270 - Lyso-ornithine lipid O-acyltransferase

IntEnz Enzyme Nomenclature
EC 2.3.1.270

Names

Reaction

• 55760 [IUBMB]
  a fatty acyl-[ACP]

  a fatty acyl-[ACP]

  GENERIC:14125

  Is ROOT: no
  ROOT compound: GENERIC:9620

  Number of residues: 1

  O-(S-fatty acylpantetheine-4ʼ-phosphoryl)-L-serine residue O-(S-fatty acylpantetheine-4'-phosphoryl)-L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:138651 Formula: C15H24N3O9PSR Charge: -1 Position: undefined ChEBI compound status: CHECKED (C)

  +

  a lyso-ornithine lipid

  a lyso-ornithine lipid

  Name origin: UniProt - CHECKED (C)

  CHEBI:138482

  Formula: C8H15N2O4R
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  an N²-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid

  an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid

  Name origin: UniProt - CHECKED (C)

  CHEBI:140663

  Formula: C9H14N2O5R2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  holo-[ACP]

  holo-[ACP]

  GENERIC:9685

  Is ROOT: no
  ROOT compound: GENERIC:9620

  Number of residues: 1

  O-(pantetheine-4ʼ-phosphoryl)-L-serine residue O-(pantetheine-4'-phosphoryl)-L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:64479 Formula: C14H25N3O8PS Charge: -1 Position: undefined ChEBI compound status: CHECKED (C)

Comments:

This bacterial enzyme catalyses the second step in the formation of ornithine lipids.

Links to other databases

References

1. Weissenmayer, B., Gao, J. L., Lopez-Lara, I. M., Geiger, O.
   Identification of a gene required for the biosynthesis of ornithine-derived lipids.
   Mol. Microbiol. 45 : 721-733 (2002). [PMID: 12139618]
2. Aygun-Sunar, S., Bilaloglu, R., Goldfine, H., Daldal, F.
   Rhodobacter capsulatus OlsA is a bifunctional enzyme active in both ornithine lipid and phosphatidic acid biosynthesis.
   J. Bacteriol. 189 : 8564-8574 (2007). [PMID: 17921310]
3. Lewenza, S., Falsafi, R., Bains, M., Rohs, P., Stupak, J., Sprott, G. D., Hancock, R. E.
   The olsA gene mediates the synthesis of an ornithine lipid in Pseudomonas aeruginosa during growth under phosphate-limiting conditions, but is not involved in antimicrobial peptide susceptibility.
   FEMS Microbiol. Lett. 320 : 95-102 (2011). [PMID: 21535098]

[EC 2.3.1.270 created 2018]