EC 2.3.1.263 - 2-amino-4-oxopentanoate thiolase

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IntEnz Enzyme Nomenclature
EC 2.3.1.263

Names

Accepted name:
2-amino-4-oxopentanoate thiolase
Other names:
AKPT
AKP thiolase
2-amino-4-ketopentanoate thiolase
Systematic name:
acetyl-CoA:D-alanine acetyltransferase

Reaction

Cofactor

Comments:

A pyridoxal 5'-phosphate enzyme. The enzyme, characterized from the bacterium Clostridium sticklandii, is part of a degradation pathway of ornithine. It is specific for acetyl-CoA and D-alanine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Jeng, I. M., Somack, R., Barker, H. A.
    Ornithine degradation in Clostridium sticklandii; pyridoxal phosphate and coenzyme A dependent thiolytic cleavage of 2-amino-4-ketopentanoate to alanine and acetyl coenzyme A.
    Biochemistry 13 : 2898-2903 (1974). [PMID: 4407783]
  2. Fonknechten, N., Perret, A., Perchat, N., Tricot, S., Lechaplais, C., Vallenet, D., Vergne, C., Zaparucha, A., Le Paslier, D., Weissenbach, J., Salanoubat, M.
    A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.
    J. Bacteriol. 191 : 3162-3167 (2009). [PMID: 19251850]

[EC 2.3.1.263 created 2017]