EC - Phloroglucinol synthase

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IntEnz Enzyme Nomenclature


Accepted name:
phloroglucinol synthase
Other name:
phlD (gene name)
Systematic name:
malonyl-CoA:malonyl-CoA malonyltransferase (decarboxylating, phloroglucinol-forming)



The enzyme, characterized from the bacterium Pseudomonas protegens Pf-5, is a type III polyketide synthase. The mechanism involves the cyclization of an activated 3,5-dioxoheptanedioate intermediate. The enzyme exhibits broad substrate specificity, and can accept C4-C12 aliphatic acyl-CoAs and phenylacetyl-CoA as the starter molecules, forming C6-polyoxoalkylated α-pyrones by sequential condensation with malonyl-CoA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Achkar, J., Xian, M., Zhao, H. and Frost, J.W.
    Biosynthesis of Phloroglucinol.
    J. Am. Chem. Soc. 127: 5332-5333 (2005).
  2. Zha, W., Rubin-Pitel, S. B., Zhao, H.
    Characterization of the substrate specificity of PhlD, a type III polyketide synthase from Pseudomonas fluorescens.
    J. Biol. Chem. 281: 32036-32047 (2006). [PMID: 16931521]

[EC created 2016]