EC 2.3.1.244 - 2-methylbutanoate polyketide synthase

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IntEnz Enzyme Nomenclature
EC 2.3.1.244

Names

Accepted name:
2-methylbutanoate polyketide synthase
Other name:
LovF
Systematic name:
acyl-CoA:malonyl-CoA C-acyltransferase (2-methylbutanoate-forming)

Reaction

Comments:

This polyketide synthase enzyme forms the (S)-2-methylbutanoate side chain during lovastatin biosynthesis by the filamentous fungus Aspergillus terreus. The overall reaction comprises a single condensation reaction followed by α-methylation, β-ketoreduction, dehydration, and α,β enoyl reduction.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Kennedy, J., Auclair, K., Kendrew, S. G., Park, C., Vederas, J. C., Hutchinson, C. R.
    Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.
    Science 284: 1368-1372 (1999). [PMID: 10334994]
  2. Meehan, M. J., Xie, X., Zhao, X., Xu, W., Tang, Y., Dorrestein, P. C.
    FT-ICR-MS characterization of intermediates in the biosynthesis of the ?-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF.
    Biochemistry 50: 287-299 (2011). [PMID: 21069965]

[EC 2.3.1.244 created 2015, modified 2016]