EC - Kdo2-lipid IVA lauroyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
Kdo2-lipid IVA lauroyltransferase
Other names:
htrB (gene name)
dodecanoyl-[acyl-carrier protein]:α-Kdo-(2→4)-α-Kdo-(2→6)-lipid IVA O-dodecanoyltransferase
lauroyl-[acyl-carrier protein]:Kdo2-lipid IVA O-lauroyltransferase
(Kdo)2-lipid IVA lauroyltransferase
α-Kdo-(2→4)-α-(2→6)-lipid IVA lauroyltransferase
Systematic name:
dodecanoyl-[acyl-carrier protein]:Kdo2-lipid IVA O-dodecanoyltransferase



The enzyme, characterized from the bacterium Escherichia coli, is involed in the biosynthesis of the phosphorylated outer membrane glycolipid lipid A.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Clementz, T., Bednarski, J. J., Raetz, C. R.
    Function of the htrB high temperature requirement gene of Escherchia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate.
    J. Biol. Chem. 271 : 12095-12102 (1996). [PMID: 8662613]
  2. Six, D. A., Carty, S. M., Guan, Z., Raetz, C. R.
    Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis.
    Biochemistry 47 : 8623-8637 (2008). [PMID: 18656959]

[EC created 2014]