IntEnz

EC 2.3.1.241 - Kdo₂-lipid IV_A lauroyltransferase

IntEnz Enzyme Nomenclature
EC 2.3.1.241

Names

Reaction

• 28442 [IUBMB]
  α-Kdo-(2→4)-α-Kdo-(2→6)-lipid IV_A

  alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA

  Name origin: UniProt - CHECKED (C)

  CHEBI:60365

  Formula: C84H148N2O37P2
  Charge: -6

  ChEBI compound status: CHECKED (C)

  

  +

  dodecanoyl-[ACP]

  dodecanoyl-[ACP]

  GENERIC:9644

  Is ROOT: no
  ROOT compound: GENERIC:9620

  Number of residues: 1

  dodecanoyl-pantetheine-4-phosphoryl-serine residue dodecanoyl-pantetheine-4-phosphoryl-serine residue Name origin: UniProt - CHECKED (C) CHEBI:65264 Formula: C26H47N3O9PS Charge: -1 Position: undefined ChEBI compound status: CHECKED (C)

  =

  dodecanoyl-(Kdo)₂-lipid IV_A

  dodecanoyl-(Kdo)2-lipid IVA

  Name origin: UniProt - CHECKED (C)

  CHEBI:61524

  Formula: C96H170N2O38P2
  Charge: -6

  ChEBI compound status: CHECKED (C)

  

  +

  holo-[ACP]

  holo-[ACP]

  GENERIC:9685

  Is ROOT: no
  ROOT compound: GENERIC:9620

  Number of residues: 1

  O-(pantetheine-4ʼ-phosphoryl)-L-serine residue O-(pantetheine-4'-phosphoryl)-L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:64479 Formula: C14H25N3O8PS Charge: -1 Position: undefined ChEBI compound status: CHECKED (C)

Comments:

The enzyme, characterized from the bacterium Escherichia coli, is involed in the biosynthesis of the phosphorylated outer membrane glycolipid lipid A.

Links to other databases

References

1. Clementz, T., Bednarski, J. J., Raetz, C. R.
   Function of the htrB high temperature requirement gene of Escherchia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate.
   J. Biol. Chem. 271 : 12095-12102 (1996). [PMID: 8662613]
2. Six, D. A., Carty, S. M., Guan, Z., Raetz, C. R.
   Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis.
   Biochemistry 47 : 8623-8637 (2008). [PMID: 18656959]

[EC 2.3.1.241 created 2014]