EC 2.3.1.238 - Monacolin J acid methylbutanoate transferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.238

Names

Accepted name:
monacolin J acid methylbutanoate transferase
Other name:
LovD
Systematic name:
monacolin J acid:(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] (S)-2-methylbutanoate transferase

Reaction

Comments:

The enzyme catalyses the ultimate reaction in the lovastatin biosynthesis pathway of the filamentous fungus Aspergillus terreus.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Kennedy, J., Auclair, K., Kendrew, S. G., Park, C., Vederas, J. C., Hutchinson, C. R.
    Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.
    Science 284 : 1368-1372 (1999). [PMID: 10334994]
  2. Xie, X., Watanabe, K., Wojcicki, W. A., Wang, C. C., Tang, Y.
    Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.
    Chem. Biol. 13 : 1161-1169 (2006). [PMID: 17113998]
  3. Xie, X., Meehan, M. J., Xu, W., Dorrestein, P. C., Tang, Y.
    Acyltransferase mediated polyketide release from a fungal megasynthase.
    J. Am. Chem. Soc. 131 : 8388-8389 (2009). [PMID: 19530726]

[EC 2.3.1.238 created 2014]