EC - 1,3,6,8-tetrahydroxynaphthalene synthase

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IntEnz Enzyme Nomenclature


Accepted name:
1,3,6,8-tetrahydroxynaphthalene synthase
Other names:
Systematic name:
malonyl-CoA C-acyl transferase (1,3,6,8-tetrahydroxynaphthalene forming)



Isolated from the fungus Colletotrichum lagenarium [1], and the bacteria Streptomyces coelicolor [2,3] and Streptomyces peucetius [4]. It only uses malonyl-CoA, without invovement of acetyl-CoA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Fujii, I., Mori, Y., Watanabe, A., Kubo, Y., Tsuji, G., Ebizuka, Y.
    Enzymatic synthesis of 1,3,6,8-tetrahydroxynaphthalene solely from malonyl coenzyme A by a fungal iterative type I polyketide synthase PKS1.
    Biochemistry 39 : 8853-8858 (2000). [PMID: 10913297]
  2. Izumikawa, M., Shipley, P. R., Hopke, J. N., O'Hare, T., Xiang, L., Noel, J. P., Moore, B. S.
    Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2).
    J. Ind. Microbiol. Biotechnol. 30 : 510-515 (2003). [PMID: 12905073]
  3. Austin, M. B., Izumikawa, M., Bowman, M. E., Udwary, D. W., Ferrer, J. L., Moore, B. S., Noel, J. P.
    Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates.
    J. Biol. Chem. 279 : 45162-45174 (2004). [PMID: 15265863]
  4. Ghimire, G. P., Oh, T. J., Liou, K., Sohng, J. K.
    Identification of a cryptic type III polyketide synthase (1,3,6,8-tetrahydroxynaphthalene synthase) from Streptomyces peucetius ATCC 27952.
    Mol. Cells 26 : 362-367 (2008). [PMID: 18612244]

[EC created 2014]