EC - Protein S-acyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
protein S-acyltransferase
Other names:
DHHC palmitoyl transferase
S-protein acyltransferase
G-protein palmitoyltransferase
Systematic name:
palmitoyl-CoA:[protein]-L-cysteine S-palmitoyltransferase



The enzyme catalyses the posttranslational protein palmitoylation that plays a role in protein-membrane interactions, protein trafficking, and enzyme activity. Palmitoylation increases the hydrophobicity of proteins or protein domains and contributes to their membrane association.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0019706
UniProtKB/Swiss-Prot: (278) [show] [UniProt]


  1. Dunphy, J. T., Greentree, W. K., Manahan, C. L., Linder, M. E.
    G-protein palmitoyltransferase activity is enriched in plasma membranes.
    J. Biol. Chem. 271 : 7154-7159 (1996). [PMID: 8636152]
  2. Veit, M., Dietrich, L. E., Ungermann, C.
    Biochemical characterization of the vacuolar palmitoyl acyltransferase.
    FEBS Lett. 540 : 101-105 (2003). [PMID: 12681491]
  3. Batistic, O.
    Genomics and localization of the Arabidopsis DHHC-cysteine-rich domain S-acyltransferase protein family.
    Plant Physiol. 160 : 1597-1612 (2012). [PMID: 22968831]
  4. Jennings, B. C., Linder, M. E.
    DHHC protein S-acyltransferases use similar ping-pong kinetic mechanisms but display different acyl-CoA specificities.
    J. Biol. Chem. 287 : 7236-7245 (2012). [PMID: 22247542]
  5. Zhou, L. Z., Li, S., Feng, Q. N., Zhang, Y. L., Zhao, X., Zeng, Y. L., Wang, H., Jiang, L., Zhang, Y.
    Protein S-ACYL Transferase10 is critical for development and salt tolerance in Arabidopsis.
    Plant Cell 25 : 1093-1107 (2013). [PMID: 23482856]

[EC created 2013]