IntEnz

EC 2.3.1.22 - 2-acylglycerol O-acyltransferase

IntEnz Enzyme Nomenclature
EC 2.3.1.22

Names

Reaction

• 32947 [IUBMB]
  a 2-acylglycerol

  a 2-acylglycerol

  Name origin: UniProt - CHECKED (C)

  CHEBI:17389

  Formula: C4H7O4R
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  an acyl-CoA

  an acyl-CoA

  Name origin: UniProt - CHECKED (C)

  CHEBI:58342

  Formula: C22H31N7O17P3SR
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  a 1,2-diacyl-sn-glycerol

  a 1,2-diacyl-sn-glycerol

  Name origin: UniProt - CHECKED (C)

  CHEBI:17815

  Formula: C5H6O5R2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  CoA

  CoA

  Name origin: UniProt - CHECKED (C)

  CHEBI:57287

  Formula: C21H32N7O16P3S
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

Comments:

Various 2-acylglycerols can act as acceptor; palmitoyl-CoA and other long-chain acyl-CoAs can act as donors. The sn-1 position and the sn-3 position are both acylated, at about the same rate.

Links to other databases

References

1. Manganaro, F. and Kuksis, A.
   Purification and preliminary characterization of 2-monoacylglycerol acyltransferase from rat intestinal villus cells.
   Can. J. Biochem. Cell Biol. 63 : 341-347 (1985). [PMID: 4016575]

[EC 2.3.1.22 created 1972, modified 1986, modified 1989]