EC - Benzalacetone synthase

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IntEnz Enzyme Nomenclature


Accepted name:
benzalacetone synthase
Other name:
Systematic name:
4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (4-hydroxybenzalacetone-forming)



A polyketide synthase that catalyses the C6-C4 skeleton of phenylbutanoids in higher plants.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Borejsza-Wysocki, W., Hrazdina, G.
    Aromatic Polyketide Synthases (Purification, Characterization, and Antibody Development to Benzalacetone Synthase from Raspberry Fruits).
    Plant Physiol. 110 : 791-799 (1996). [PMID: 12226219]
  2. Abe, I., Takahashi, Y., Morita, H., Noguchi, H.
    Benzalacetone synthase. A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatum.
    Eur. J. Biochem. 268 : 3354-3359 (2001). [PMID: 11389739]
  3. Zheng, D., Hrazdina, G.
    Molecular and biochemical characterization of benzalacetone synthase and chalcone synthase genes and their proteins from raspberry (Rubus idaeus L.).
    Arch. Biochem. Biophys. 470 : 139-145 (2008). [PMID: 18068110]
  4. Morita, H., Shimokawa, Y., Tanio, M., Kato, R., Noguchi, H., Sugio, S., Kohno, T., Abe, I.
    A structure-based mechanism for benzalacetone synthase from Rheum palmatum.
    Proc. Natl. Acad. Sci. U.S.A. 107 : 669-673 (2010). [PMID: 20080733]

[EC created 2013]