EC 2.3.1.211 - Bisdemethoxycurcumin synthase

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IntEnz Enzyme Nomenclature
EC 2.3.1.211

Names

Accepted name:
bisdemethoxycurcumin synthase
Other names:
CUS
CURS
curcuminoid synthase [ambiguous]
Systematic name:
4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (bisdemethoxycurcumin-forming)

Reaction

Comments:

A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyses the formation of the C6-C7-C6 diarylheptanoid scaffold of bisdemethoxycurcumin. Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes (EC 2.3.1.218, phenylpropanoyl-diketide CoA synthase and EC 2.3.1.217, curcumin synthase), the diketide intermediate formed by this enzyme remains within the enzyme's cavity and is not released to the environment.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102452
UniProtKB/Swiss-Prot:

References

  1. Morita, H., Wanibuchi, K., Nii, H., Kato, R., Sugio, S., Abe, I.
    Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa.
    Proc. Natl. Acad. Sci. U.S.A. 107 : 19778-19783 (2010). [PMID: 21041675]

[EC 2.3.1.211 created 2013]