EC - β-ketodecanoyl-[acyl-carrier-protein] synthase

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IntEnz Enzyme Nomenclature


Accepted name:
β-ketodecanoyl-[acyl-carrier-protein] synthase
Systematic name:
octanoyl-CoA:malonyl-[acyl-carrier protein] C-heptanoylltransferase (decarboxylating, CoA-forming)



This enzyme, which has been characterized from the bacterium Pseudomonas aeruginosa PAO1, catalyses the condensation of octanoyl-CoA, obtained from exogenously supplied fatty acids via β-oxidation, with malonyl-[acp], forming 3-oxodecanoyl-[acp], an intermediate of the fatty acid elongation cycle. The enzyme provides a shunt for β-oxidation degradation intermediates into de novo fatty acid biosynthesis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Yuan, Y., Leeds, J. A., Meredith, T. C.
    Pseudomonas aeruginosa Directly Shunts beta-Oxidation Degradation Intermediates into De Novo Fatty Acid Biosynthesis.
    J. Bacteriol. 194 : 5185-5196 (2012). [PMID: 22753057]

[EC created 2012]