EC 2.3.1.207 - β-ketodecanoyl-[acyl-carrier-protein] synthase

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IntEnz Enzyme Nomenclature
EC 2.3.1.207

Names

Accepted name:
β-ketodecanoyl-[acyl-carrier-protein] synthase
Systematic name:
octanoyl-CoA:malonyl-[acyl-carrier protein] C-heptanoylltransferase (decarboxylating, CoA-forming)

Reaction

Comments:

This enzyme, which has been characterized from the bacterium Pseudomonas aeruginosa PAO1, catalyses the condensation of octanoyl-CoA, obtained from exogenously supplied fatty acids via β-oxidation, with malonyl-[acp], forming 3-oxodecanoyl-[acp], an intermediate of the fatty acid elongation cycle. The enzyme provides a shunt for β-oxidation degradation intermediates into de novo fatty acid biosynthesis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Yuan, Y., Leeds, J. A., Meredith, T. C.
    Pseudomonas aeruginosa Directly Shunts beta-Oxidation Degradation Intermediates into De Novo Fatty Acid Biosynthesis.
    J. Bacteriol. 194: 5185-5196 (2012). [PMID: 22753057]

[EC 2.3.1.207 created 2012]