EC - 3,5,7-trioxododecanoyl-CoA synthase

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IntEnz Enzyme Nomenclature


Accepted name:
3,5,7-trioxododecanoyl-CoA synthase
Other names:
TKS [ambiguous]
olivetol synthase [incorrect]
Systematic name:
malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming)



A polyketide synthase catalysing the first committed step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme was previously thought to also function as a cyclase, but the cyclization is now known to be catalysed by EC, olivetolic acid cyclase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Taura, F., Tanaka, S., Taguchi, C., Fukamizu, T., Tanaka, H., Shoyama, Y., Morimoto, S.
    Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway.
    FEBS Lett. 583 : 2061-2066 (2009). [PMID: 19454282]
  2. Gagne, S. J., Stout, J. M., Liu, E., Boubakir, Z., Clark, S. M., Page, J. E.
    Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides.
    Proc. Natl. Acad. Sci. U.S.A. 109 : 12811-12816 (2012). [PMID: 22802619]

[EC created 2012]