EC 2.3.1.204 - Octanoyl-[GcvH]:protein N-octanoyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.204

Names

Accepted name:
octanoyl-[GcvH]:protein N-octanoyltransferase
Other names:
LipL
octanoyl-[GcvH]:E2 amidotransferase
ywfL (gene name)
Systematic name:
[glycine cleavage system H]-N6-octanoyl-L-lysine:[lipoyl-carrier protein]-N6-L-lysine octanoyltransferase

Reaction

Comments:

In the bacterium Bacillus subtilis it has been shown that the enzyme catalyses the amidotransfer of the octanoyl moiety from [glycine cleavage system H]-N6-octanoyl-L-lysine (i.e. octanoyl-GcvH) to the E2 subunit (dihydrolipoamide acetyltransferase) of pyruvate dehydrogenase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (16) [show] [UniProt]

References

  1. Christensen, Q. H., Martin, N., Mansilla, M. C., de Mendoza, D., Cronan, J. E.
    A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis.
    Mol. Microbiol. 80 : 350-363 (2011). [PMID: 21338421]
  2. Martin, N., Christensen, Q. H., Mansilla, M. C., Cronan, J. E., de Mendoza, D.
    A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis.
    Mol. Microbiol. 80 : 335-349 (2011). [PMID: 21338420]

[EC 2.3.1.204 created 2012]