EC 2.3.1.201 - UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.201

Names

Accepted name:
UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase
Other names:
WbpD
WlbB
Systematic name:
acetyl-CoA:UDP-2-acetamido-3-amino-2,3-dideoxy-α-D-glucuronate N-acetyltransferase

Reaction

Comments:

This enzyme participates in the biosynthetic pathway for UDP-α-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-α-D-mannuronic acid), an important precursor of B-band lipopolysaccharide.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Westman, E. L., McNally, D. J., Charchoglyan, A., Brewer, D., Field, R. A., Lam, J. S.
    Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa.
    J. Biol. Chem. 284 : 11854-11862 (2009). [PMID: 19282284]
  2. Larkin, A., Imperiali, B.
    Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1.
    Biochemistry 48 : 5446-5455 (2009). [PMID: 19348502]

[EC 2.3.1.201 created 2012]