IntEnz

EC 2.3.1.20 - Diacylglycerol O-acyltransferase

IntEnz Enzyme Nomenclature
EC 2.3.1.20

Names

Reaction

• 10868 [IUBMB]
  a 1,2-diacyl-sn-glycerol

  a 1,2-diacyl-sn-glycerol

  Name origin: UniProt - CHECKED (C)

  CHEBI:17815

  Formula: C5H6O5R2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  an acyl-CoA

  an acyl-CoA

  Name origin: UniProt - CHECKED (C)

  CHEBI:58342

  Formula: C22H31N7O17P3SR
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  =

  a triacyl-sn-glycerol

  a triacyl-sn-glycerol

  Name origin: UniProt - CHECKED (C)

  CHEBI:64615

  Formula: C6H5O6R3
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  CoA

  CoA

  Name origin: UniProt - CHECKED (C)

  CHEBI:57287

  Formula: C21H32N7O16P3S
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

Comments:

Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.

Links to other databases

References

1. Coleman, R. and Bell, R.M.
   Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols.
   J. Biol. Chem. 251: 4537-4543 (1976). [PMID: 947894]
2. Grigor, M.R., Bell, R.M.
   Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis.
   Biochim. Biophys. Acta 712: 464-472 (1982). [PMID: 6289909]
3. Kawasaki, T. and Snyder, F.
   Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells.
   J. Biol. Chem. 263: 2593-2596 (1988). [PMID: 3422635]
4. Weiss, S.B., Kennedy, E.P. and Kiyasu, J.Y.
   The enzymatic synthesis of triglycerides.
   J. Biol. Chem. 235: 40-44 (1960). [PMID: 13843753]

[EC 2.3.1.20 created 1965]