EC - Diacylglycerol O-acyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
diacylglycerol O-acyltransferase
Other names:
1,2-diacylglycerol acyltransferase
diacylglycerol acyltransferase
diglyceride O-acyltransferase
diglyceride acyltransferase
palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase
acyl-CoA:1,2-diacylglycerol O-acyltransferase
Systematic name:
acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase



Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004144
CAS Registry Number: 9029-98-5
UniProtKB/Swiss-Prot: (106) [show] [UniProt]


  1. Coleman, R. and Bell, R.M.
    Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols.
    J. Biol. Chem. 251 : 4537-4543 (1976). [PMID: 947894]
  2. Grigor, M.R., Bell, R.M.
    Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis.
    Biochim. Biophys. Acta 712 : 464-472 (1982). [PMID: 6289909]
  3. Kawasaki, T. and Snyder, F.
    Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells.
    J. Biol. Chem. 263 : 2593-2596 (1988). [PMID: 3422635]
  4. Weiss, S.B., Kennedy, E.P. and Kiyasu, J.Y.
    The enzymatic synthesis of triglycerides.
    J. Biol. Chem. 235 : 40-44 (1960). [PMID: 13843753]

[EC created 1965]