EC 2 - Transferases
EC 2.3 - Acyltransferases
EC 2.3.1 - Transferring groups other than amino-acyl groups
EC 2.3.1.20 - Diacylglycerol O-acyltransferase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.3.1.20
Names
Accepted name:
diacylglycerol O-acyltransferase
Other
names:
1,2-diacylglycerol acyltransferase
diacylglycerol acyltransferase
diglyceride O-acyltransferase
diglyceride acyltransferase
palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase
acyl-CoA:1,2-diacylglycerol O-acyltransferase
diacylglycerol acyltransferase
diglyceride O-acyltransferase
diglyceride acyltransferase
palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase
acyl-CoA:1,2-diacylglycerol O-acyltransferase
Systematic name:
acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
Reaction
- acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol
Comments:
Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.
Links to other databases
Gene Ontology:
GO:0004144
CAS Registry Number:
9029-98-5
References
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Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols.J. Biol. Chem. 251 : 4537-4543 (1976). [PMID: 947894]
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Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis.Biochim. Biophys. Acta 712 : 464-472 (1982). [PMID: 6289909]
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Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells.J. Biol. Chem. 263 : 2593-2596 (1988). [PMID: 3422635]
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The enzymatic synthesis of triglycerides.J. Biol. Chem. 235 : 40-44 (1960). [PMID: 13843753]
[EC 2.3.1.20 created 1965]