EC - TRNAMet cytidine acetyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
tRNAMet cytidine acetyltransferase
Other names:
Systematic name:
acetyl-CoA:[elongator tRNAMet]-cytidine34 N4-acetyltransferase (ATP-hydrolysing)



The enzyme acetylates the wobble base C34 of the CAU anticodon of elongation-specific tRNAMet. Escherichia coli TmcA strictly discriminates elongator tRNAMet from tRNAIle, which is structurally similar and has the same anticodon loop, mainly by recognizing the C27-G43 pair in the anticodon stem. The enzyme can use GTP in place of ATP for formation of N4-acetylcytidine [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (21) [show] [UniProt]


  1. Ikeuchi, Y., Kitahara, K., Suzuki, T.
    The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon.
    EMBO J. 27 : 2194-2203 (2008). [PMID: 18668122]
  2. Chimnaronk, S., Suzuki, T., Manita, T., Ikeuchi, Y., Yao, M., Suzuki, T., Tanaka, I.
    RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon.
    EMBO J. 28 : 1362-1373 (2009). [PMID: 19322199]

[EC created 2011]