EC 2.3.1.190 - Acetoin dehydrogenase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.3.1.190

Names

Accepted name:
acetoin dehydrogenase
Other names:
acetoin dehydrogenase complex
acetoin dehydrogenase enzyme system
AoDH ES
Systematic name:
acetyl-CoA:acetoin O-acetyltransferase

Reaction

Cofactor

Comments:

Requires thiamine diphosphate. This enzyme, which belongs to the family of 2-oxo acid dehydrogenase complexes, catalyses the oxidative-hydrolytic cleavage of acetoin to acetaldehyde and acetyl-CoA in many bacterial strains, both aerobic and anaerobic. The enzyme is composed of multiple copies of three enzymatic components:acetoin oxidoreductase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoyl dehydrogenase (E3).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00073
Structural data: CSA , EC2PDB

References

  1. Priefert, H., Hein, S., Kruger, N., Zeh, K., Schmidt, B., Steinbuchel, A.
    Identification and molecular characterization of the Alcaligenes eutrophus H16 aco operon genes involved in acetoin catabolism.
    J. Bacteriol. 173: 4056-4071 (1991). [PMID: 2061286]
  2. Oppermann, F. B., Steinbuchel, A.
    Identification and molecular characterization of the aco genes encoding the Pelobacter carbinolicus acetoin dehydrogenase enzyme system.
    J. Bacteriol. 176: 469-485 (1994). [PMID: 8110297]
  3. Kruger, N., Oppermann, F. B., Lorenzl, H., Steinbuchel, A.
    Biochemical and molecular characterization of the Clostridium magnum acetoin dehydrogenase enzyme system.
    J. Bacteriol. 176: 3614-3630 (1994). [PMID: 8206840]
  4. Huang, M., Oppermann, F. B., Steinbuchel, A.
    Molecular characterization of the Pseudomonas putida 2,3-butanediol catabolic pathway.
    FEMS Microbiol. Lett. 124: 141-150 (1994). [PMID: 7813883]
  5. Huang, M., Oppermann-Sanio, F. B., Steinbuchel, A.
    Biochemical and molecular characterization of the Bacillus subtilis acetoin catabolic pathway.
    J. Bacteriol. 181: 3837-3841 (1999). [PMID: 10368162]

[EC 2.3.1.190 created 2010]