EC 2.3.1.187 - Acetyl-S-ACP:malonate ACP transferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.187

Names

Accepted name:
acetyl-S-ACP:malonate ACP transferase
Other names:
acetyl-S-ACP:malonate ACP-SH transferase
acetyl-S-acyl-carrier protein:malonate acyl-carrier-protein-transferase
MdcA
MadA
ACP transferase
malonate/acetyl-CoA transferase
malonate:ACP transferase
acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase
Systematic name:
acetyl-[acyl-carrier-protein]:malonate S-[acyl-carrier-protein]transferase

Reaction

Comments:

This is the first step in the catalysis of malonate decarboxylation and involves the exchange of an acetyl thioester residue bound to the activated acyl-carrier protein (ACP) subunit of the malonate decarboxylase complex for a malonyl thioester residue [2]. This enzyme forms the α subunit of the multienzyme complexes biotin-independent malonate decarboxylase (EC 4.1.1.88) and biotin-dependent malonate decarboxylase (EC 7.2.4.4). The enzyme can also use acetyl-CoA as a substrate but more slowly [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Hilbi, H. and Dimroth, P.
    Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase.
    Arch. Microbiol. 162 : 48-56 (1994). [PMID: 18251085]
  2. Hoenke, S., Schmid, M. and Dimroth, P.
    Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli.
    Eur. J. Biochem. 246 : 530-538 (1997). [PMID: 9208947]
  3. Koo, J.H. and Kim, Y.S.
    Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus.
    Eur. J. Biochem. 266 : 683-690 (1999). [PMID: 10561613]
  4. Chohnan, S., Akagi, K. and Takamura, Y.
    Functions of malonate decarboxylase subunits from Pseudomonas putida.
    Biosci. Biotechnol. Biochem. 67 : 214-217 (2003). [PMID: 12619701]
  5. Dimroth, P. and Hilbi, H.
    Enzymic and genetic basis for bacterial growth on malonate.
    Mol. Microbiol. 25 : 3-10 (1997). [PMID: 11902724]

[EC 2.3.1.187 created 2008, modified 2018]