EC - (R)-citramalate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
(R)-citramalate synthase
Other name:
Systematic name:



One of the enzymes involved in a novel pyruvate pathway for isoleucine biosynthesis that is found in some, mainly archaeal, bacteria [1,2]. The enzyme can be inhibited by isoleucine, the end-product of the pathway, but not by leucine [2]. The enzyme is highly specific for pyruvate as substrate, as the 2-oxo acids 3-methyl-2-oxobutanoate, 2-oxobutanoate, 4-methyl-2-oxopentanoate, 2-oxohexanoate and 2-oxoglutarate cannot act as substrate [1,2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043714
UniProtKB/Swiss-Prot: (14) [show] [UniProt]


  1. Howell, D.M., Xu, H. and White, R.H.
    (R)-Citramalate synthase in methanogenic archaea.
    J. Bacteriol. 181: 331-333 (1999). [PMID: 9864346]
  2. Xu, H., Zhang, Y., Guo, X., Ren, S., Staempfli, A.A., Chiao, J., Jiang, W. and Zhao, G.
    Isoleucine biosynthesis in Leptospira interrogans serotype 1ai strain 56601 proceeds via a threonine-independent pathway.
    J. Bacteriol. 186: 5400-5409 (2004). [PMID: 15292141]

[EC created 2007]