EC 2.3.1.178 - Diaminobutyrate acetyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.178

Names

Accepted name:
diaminobutyrate acetyltransferase
Other names:
L-2,4-diaminobutyrate acetyltransferase
L-2,4-diaminobutanoate acetyltransferase
EctA
diaminobutyric acid acetyltransferase
DABA acetyltransferase
2,4-diaminobutanoate acetyltransferase
DAB acetyltransferase
DABAcT
acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase
Systematic name:
acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase

Reaction

Cofactor

Comments:

Requires Na+ or K+ for maximal activity [3]. Ornithine, lysine, aspartate, and α-, β- and γ-aminobutanoate cannot act as substrates [3]. However, acetyl-CoA can be replaced by propanoyl-CoA, although the reaction proceeds more slowly [3]. Forms part of the ectoine-biosynthesis pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC51186
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033816
UniProtKB/Swiss-Prot: (18) [show] [UniProt]

References

  1. Peters, P., Galinski, E.A. and Truper, H.G.
    The biosynthesis of ectoine.
    FEMS Microbiol. Lett. 71: 157-162 (1990).
  2. Ono, H., Sawada, K., Khunajakr, N., Tao, T., Yamamoto, M., Hiramoto, M., Shinmyo, A., Takano, M. and Murooka, Y.
    Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata.
    J. Bacteriol. 181: 91-99 (1999). [PMID: 9864317]
  3. Reshetnikov, A.S., Mustakhimov, I.I., Khmelenina, V.N. and Trotsenko, Y.A.
    Cloning, purification, and characterization of diaminobutyrate acetyltransferase from the halotolerant methanotroph Methylomicrobium alcaliphilum 20Z.
    Biochemistry Mosc. 70: 878-883 (2005). [PMID: 16212543]
  4. Kuhlmann, A.U. and Bremer, E.
    Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
    Appl. Environ. Microbiol. 68: 772-783 (2002). [PMID: 11823218]
  5. Louis, P. and Galinski, E.A.
    Characterization of genes for the biosynthesis of the compatible solute ectoine from Marinococcus halophilus and osmoregulated expression in Escherichia coli.
    Microbiology 143: 1141-1149 (1997). [PMID: 9141677]

[EC 2.3.1.178 created 2006]